Riki Kawaguchi, Jiamei Yu, jane Honda, jane Hu, Julian Whitelegge, Peipei Ping, Patrick Wiita, Dean Bok, and also Hui Sun
Vitamin A has actually diverse biological functions. That is transported in the blood as a facility with retinol binding protein (RBP), but the molecule mechanism by which vitamin A is soaked up by cells from the vitamin A–RBP facility is not plainly understood. We identified in bovine retinal colours epithelium cells STRA6, a multitransmembrane domain protein, as a certain membrane receptor for RBP. STRA6 binds to RBP through high affinity and has durable vitamin A uptake activity from the vitamin A–RBP complex. The is extensively expressed in embryonic breakthrough and in adult organ systems. The RBP receptor represents a major physiological mediator of to move vitamin A uptake.

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Note added in proof: A recent human genetic study (41) uncovered that mutations in the person STRA6 gene are connected with prevalent birth defects in multiple organ systems. This is continuous with the expression of STRA6 and also the diverse functions of vitamin A in embryonic development.
D. S. Goodman, in The Retinoids, M. B. Sporn, A. B. Boberts, D. S. Goodman, Eds. (Academic Press, new York, 1984), vol. 2, pp. 41–88.
A. Sivaprasadarao, J. B. Findlay, in Vitamin A in Health and Disease, R. Blomhoff, Ed. (Marcel Dekker, new York, 1994), pp. 87–117.
A. Vahlquist, in Vitamin A in Health and Disease, R. Blomhoff, Ed. (Marcel Dekker, new York, 1994), pp. 365–424.
We thank E. Wright, G. Travis, K. Philipson, J. Nathans, B. Khakh, T. Vondriska, and B. Ribalet for useful discussions and K. Philipson, J. Nathans, A. Rattner, G. Travis, and E. Bright for vital reading of the manuscript. Sustained by sponsor from the Stein-Oppenheimer structure and the Ruth and Milton Steinbach structure (H.S.). R.K. Was sustained by NIH training approve 5T32EY07026.
room of Physiology, David Geffen college of medicine at UCLA, 650 Charles E. Young drive South, Los Angeles, CA 90095, USA.
Jules Stein Eye Institute, David Geffen college of medicine at UCLA, 100 Stein Plaza, 650 Charles E. Young drive South, Los Angeles, CA 90095, USA.
room of Physiology, David Geffen school of medication at UCLA, 650 Charles E. Young drive South, Los Angeles, CA 90095, USA.
room of Physiology, David Geffen college of medication at UCLA, 650 Charles E. Young journey South, Los Angeles, CA 90095, USA.
Jules Stein Eye Institute, David Geffen institution of medication at UCLA, 100 Stein Plaza, 650 Charles E. Young drive South, Los Angeles, CA 90095, USA.

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Pasarow fixed Spectrometry Laboratory, Semel Institute, David Geffen college of medicine at UCLA, 760 Westwood Plaza, Los Angeles, CA 90024, USA.
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